Beilstein J. Nanotechnol.2020,11, 568–582, doi:10.3762/bjnano.11.45
light on the biomechanical changes for early diagnosis of tumor transformation and progression at single-cell level.
Keywords: atomic force microscopy (AFM); cancerinvasion; cancer migration; ovarian cancer cells; viscoelasticity; Introduction
Ovarian cancer is a lethal gynecological malignancy with
with cancerinvasion after anticancer drug treatment [24][25]. Echinomycin serves as a potential therapeutic agent through the induction of cell apoptosis, which is typically used in the treatment of epithelial cancers, including ovary, breast and prostate cancers [26][27][28][29]. Inhibitory
mechanisms of cancerinvasion and metastasis based on chemotherapy can be beneficial for both biomechanical research and clinical applications [30][31]. Therefore, the present study examined the elasticity and viscosity through AFM, and cell migration, invasion and microfilament density through cell
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Figure 1:
Histograms of viscoelastic properties of ovarian cells. Cell elasticity and viscosity were examined...
Beilstein J. Nanotechnol.2014,5, 447–457, doi:10.3762/bjnano.5.52
.
It is well established that actin filaments are mostly responsible for the mechanical properties of cells that are measured by the AFM. Therefore, there have been several attempts trying to show the correlation between the 2D-organization of actin filaments and cells stiffness in relation to cancer
invasion. The relation between the stiffness of cancer cells and the 2D-organization of the actin cytoskeleton has been reported for breast [3], thyroid [11] and ovarian [21] cancers. For stiffer cells, the actin filaments distribution usually revealed two types of filament organization, i.e., an actin